Monitoring intravesical bacillus Calmette-Guerin treatment of bladder carcinoma with flow cytometry

L. Staiano-Coico, J. Huffman, R. Wolf, C. M. Pinsky, H. W. Herr, W. F. Whitmore, H. F. Oettgen, Z. Darzynkiewicz, M. R. Melamed

Research output: Contribution to journalArticlepeer-review

Abstract

Flow cytometry of bladder irrigation specimens was studied in 22 patients with low stage bladder carcinoma who were treated by transurethral resection of visible tumor followed in 3 to 5 weeks by a course of intravesical bacillus Calmette-Guerin. The most informative examinations were just before the first bacillus Calmette-Guerin treatment, 6 weeks after completing a 6-week course of treatment (3 months) and at 9 months. Of the patients 10 had recurrent tumors after therapy; recurrence was anticipated correctly by flow cytometry at the 12-week followup examination in 6 of the 10 patients and suspected in another. Of 12 patients who remained clinically free of disease for a minimum of 15 months after bacillus Calmette-Guerin therapy flow cytometry identified correctly 7 at 12 weeks, while 1 had a partial response and the remaining 4 reverted to a negative status at 9 months. Of interest, only 4 of the 22 patients were free of disease by flow cytometry at the start of bacillus Calmette-Guerin treatment despite attempted ablation of the tumor by transurethral resection, suggesting that intravesical administration of bacillus Calmette-Guerin destroys existing carcinoma in situ in some cases.

Original languageEnglish (US)
Pages (from-to)786-788
Number of pages3
JournalJournal of Urology
Volume133
Issue number5
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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