Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP

Angad P. Mehta; Sameh H. Abdelwahed; Tadhg P. Begley

doi:10.1016/j.bbapap.2015.04.008

Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP

Angad P. Mehta, Sameh H. Abdelwahed, Tadhg P. Begley

Research output: Contribution to journal › Review article › peer-review

Abstract

Abstract The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2′ and C3′ carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.

Original language	English (US)
Article number	39571
Pages (from-to)	1073-1077
Number of pages	5
Journal	Biochimica et Biophysica Acta - Proteins and Proteomics
Volume	1854
Issue number	9
DOIs	https://doi.org/10.1016/j.bbapap.2015.04.008
State	Published - Dec 20 2015
Externally published	Yes

Keywords

Intermediate trapping
Mechanism
MoaA
Molybtopterin
Substrate analog

ASJC Scopus subject areas

Analytical Chemistry
Biophysics
Biochemistry
Molecular Biology

Online availability

10.1016/j.bbapap.2015.04.008

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Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP. / Mehta, Angad P.; Abdelwahed, Sameh H.; Begley, Tadhg P.
In: Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1854, No. 9, 39571, 20.12.2015, p. 1073-1077.

Research output: Contribution to journal › Review article › peer-review

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AU - Begley, Tadhg P.

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Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP

Abstract

Keywords

ASJC Scopus subject areas

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