Molluscan models: Crepidula fornicata

Jonathan Q. Henry, Deirdre C. Lyons

Research output: Contribution to journalReview article

Abstract

Gastropod snails in the genus Crepidula have emerged as model systems for studying a metazoan super clade, the Spiralia. Recent work on one species in particular, Crepidula fornicata, has produced high-resolution cell lineage fate maps, details of morphogenetic events during gastrulation, key insights into the molecular underpinnings of early development, and the first demonstration of CRISPR/Cas9 genome editing in the Spiralia. Furthermore, invasive species of Crepidula are a significant ecological threat, while one of these, C. fornicata, is also being harvested for food. This review highlights progress towards developing these animals as models for evolutionary, developmental, and ecological studies. Such studies have contributed greatly to our understanding of biology in a major clade of bilaterians. This information may also help us to control and cultivate these snails.

Original languageEnglish (US)
Pages (from-to)138-148
Number of pages11
JournalCurrent Opinion in Genetics and Development
Volume39
DOIs
StatePublished - Aug 1 2016

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Snails
Clustered Regularly Interspaced Short Palindromic Repeats
Introduced Species
Gastrulation
Gastropoda
Cell Lineage
Animal Models
Food
Gene Editing

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Molluscan models : Crepidula fornicata. / Henry, Jonathan Q.; Lyons, Deirdre C.

In: Current Opinion in Genetics and Development, Vol. 39, 01.08.2016, p. 138-148.

Research output: Contribution to journalReview article

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