Molecular contrast in optical coherence tomography (OCT) is demonstrated by use of coherent anti-Stokes Raman scattering (CARS) for molecular sensitivity. Femtosecond laser pulses are focused into a sample by use of a low-numerical-aperture lens to generate CARS photons, and the backreflected CARS signal is interferometrically measured. With the chemical selectivity provided by CARS and the advanced imaging capabilities of OCT, this technique may be useful for molecular contrast imaging in biological tissues. CARS can be generated and interferometrically measured over at least 600 μm of the depth of field of a low-numerical-aperture objective.

Original languageEnglish (US)
Pages (from-to)495-497
Number of pages3
JournalOptics Letters
Issue number5
StatePublished - Mar 1 2005

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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