Molecular theranostics: A primer for the imaging professional

Daniel Y. Lee, King C.P. Li

Research output: Contribution to journalReview article

Abstract

OBJECTIVE. A theranostic system integrates some form of diagnostic testing to determine the presence of a molecular target for which a specific drug is intended. Molecular imaging serves this diagnostic function and provides powerful means for noninvasively detecting disease. We briefly review the paradigms rooted in nuclear medicine and highlight recent advances in this field. We also explore how nanometer-sized complexes, called nanomedicines, present an excellent theranostic platform applicable to both drug discovery and clinical use. CONCLUSION. For imagers, molecular theranostics represents a powerful emerging platform that intimately couples targeted therapeatic entities with noninvasive imaging that yields information on the presence of defined molecular targets before, during, and after cognate therapy.

Original languageEnglish (US)
Pages (from-to)318-324
Number of pages7
JournalAmerican Journal of Roentgenology
Volume197
Issue number2
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Cancer therapy
  • Molecular imaging
  • Molecular medicine
  • Nanomedicine
  • Theranostics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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