Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

Hugo C. Ong, Jonathan F. Arambula, Sreenivasa Rao Ramisetty, Anne M. Baranger, Steven C. Zimmerman

Research output: Contribution to journalArticle

Abstract

7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.

Original languageEnglish (US)
Pages (from-to)668-670
Number of pages3
JournalChemical Communications
Issue number6
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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