Abstract
Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.
Original language | English (US) |
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Pages (from-to) | 4170-4173 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 48 |
Issue number | 23 |
DOIs | |
State | Published - May 25 2009 |
Externally published | Yes |
Keywords
- Contrast agents
- Gold
- Molecular imaging
- Nanoparticles
- Photoacoustic tomography
ASJC Scopus subject areas
- General Chemistry
- Catalysis