Abstract
In the absence of atomic structures of high-density lipoproteins in their lipid-bound states, many molecular models have been produced based on experimental data. Using molecular dynamics, we show that a recently proposed "solar-flares" model of discoidal high-density lipoprotein is implausible. Our simulations show a collapse of the protruding solar-flare loops and a notable protein rearrangement due to an energetically unfavorable orientation of the hydrophobic protein surface toward the aqueous solvent.
Original language | English (US) |
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Pages (from-to) | L87-L89 |
Journal | Biophysical journal |
Volume | 94 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 2008 |
ASJC Scopus subject areas
- Biophysics