Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes

S. W. Davis, F. Castinetti, L. R. Carvalho, B. S. Ellsworth, M. A. Potok, R. H. Lyons, M. L. Brinkmeier, L. T. Raetzman, P. Carninci, A. H. Mortensen, Y. Hayashizaki, I. J.P. Arnhold, B. B. Mendonça, T. Brue, S. A. Camper

Research output: Contribution to journalReview article

Abstract

Defects in pituitary gland organogenesis are sometimes associated with congenital anomalies that affect head development. Lesions in transcription factors and signaling pathways explain some of these developmental syndromes. Basic research studies, including the characterization of genetically engineered mice, provide a mechanistic framework for understanding how mutations create the clinical characteristics observed in patients. Defects in BMP, WNT, Notch, and FGF signaling pathways affect induction and growth of the pituitary primordium and other organ systems partly by altering the balance between signaling pathways. The PITX and LHX transcription factor families influence pituitary and head development and are clinically relevant. A few later-acting transcription factors have pituitary-specific effects, including PROP1, POU1F1 (PIT1), and TPIT (TBX19), while others, such as NeuroD1 and NR5A1 (SF1), are syndromic, influencing development of other endocrine organs. We conducted a survey of genes transcribed in developing mouse pituitary to find candidates for cases of pituitary hormone deficiency of unknown etiology. We identified numerous transcription factors that are members of gene families with roles in syndromic or non-syndromic pituitary hormone deficiency. This collection is a rich source for future basic and clinical studies.

Original languageEnglish (US)
Pages (from-to)4-19
Number of pages16
JournalMolecular and Cellular Endocrinology
Volume323
Issue number1
DOIs
StatePublished - Jul 1 2010

Fingerprint

Organogenesis
Regulator Genes
Transcription Factors
Genes
Pituitary Hormones
Head
Defects
Pituitary Gland
Mutation
Growth
Research

Keywords

  • Beta helix-loop-helix (bHLH)
  • Forkhead
  • High mobility group (HMG)
  • Hypopituitarism
  • T-box

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Davis, S. W., Castinetti, F., Carvalho, L. R., Ellsworth, B. S., Potok, M. A., Lyons, R. H., ... Camper, S. A. (2010). Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Molecular and Cellular Endocrinology, 323(1), 4-19. https://doi.org/10.1016/j.mce.2009.12.012

Molecular mechanisms of pituitary organogenesis : In search of novel regulatory genes. / Davis, S. W.; Castinetti, F.; Carvalho, L. R.; Ellsworth, B. S.; Potok, M. A.; Lyons, R. H.; Brinkmeier, M. L.; Raetzman, L. T.; Carninci, P.; Mortensen, A. H.; Hayashizaki, Y.; Arnhold, I. J.P.; Mendonça, B. B.; Brue, T.; Camper, S. A.

In: Molecular and Cellular Endocrinology, Vol. 323, No. 1, 01.07.2010, p. 4-19.

Research output: Contribution to journalReview article

Davis, SW, Castinetti, F, Carvalho, LR, Ellsworth, BS, Potok, MA, Lyons, RH, Brinkmeier, ML, Raetzman, LT, Carninci, P, Mortensen, AH, Hayashizaki, Y, Arnhold, IJP, Mendonça, BB, Brue, T & Camper, SA 2010, 'Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes', Molecular and Cellular Endocrinology, vol. 323, no. 1, pp. 4-19. https://doi.org/10.1016/j.mce.2009.12.012
Davis, S. W. ; Castinetti, F. ; Carvalho, L. R. ; Ellsworth, B. S. ; Potok, M. A. ; Lyons, R. H. ; Brinkmeier, M. L. ; Raetzman, L. T. ; Carninci, P. ; Mortensen, A. H. ; Hayashizaki, Y. ; Arnhold, I. J.P. ; Mendonça, B. B. ; Brue, T. ; Camper, S. A. / Molecular mechanisms of pituitary organogenesis : In search of novel regulatory genes. In: Molecular and Cellular Endocrinology. 2010 ; Vol. 323, No. 1. pp. 4-19.
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