Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

Deborah Leckband

doi:10.1080/00218460490465713

Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

Research output: Contribution to journal › Article › peer-review

Abstract

This review highlights recent surface force measurements of the molecular interactions of protein adhesives. These studies identified novel molecular-binding mechanisms that are intimately linked to the protein structures. Central to these findings is the precise force and distance sensitivity achieved with the surface force apparatus. They illustrate that a mechanistic understanding of the nanomechanical properties of biomolecular adhesives requires measurements of both the strength of adhesion and the range of the protein interactions.

Original language	English (US)
Pages (from-to)	409-432
Number of pages	24
Journal	Journal of Adhesion
Volume	80
Issue number	5
DOIs	https://doi.org/10.1080/00218460490465713
State	Published - May 2004

Keywords

Cadherin
CD2
Cell adhesion
NCAM
Polysialic acid
Surface force apparatus

ASJC Scopus subject areas

Chemical Engineering(all)
Materials Science(all)
Mechanics of Materials
Computational Mechanics

Online availability

10.1080/00218460490465713

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title = "Molecular mechanisms of cell adhesion: New perspectives from surface force measurements",

abstract = "This review highlights recent surface force measurements of the molecular interactions of protein adhesives. These studies identified novel molecular-binding mechanisms that are intimately linked to the protein structures. Central to these findings is the precise force and distance sensitivity achieved with the surface force apparatus. They illustrate that a mechanistic understanding of the nanomechanical properties of biomolecular adhesives requires measurements of both the strength of adhesion and the range of the protein interactions.",

keywords = "Cadherin, CD2, Cell adhesion, NCAM, Polysialic acid, Surface force apparatus",

author = "Deborah Leckband",

note = "Funding Information: Received 16 December 2003; in final form 25 March 2004. One of a collection of papers honoring Jacob Israelachvili, the recipient in February 2003 of The Adhesion Society Award for Excellence in Adhesion Science, Sponsored by 3M. This work was supported by NIH 1 RO1 GM63536 and by NIH 2 RO1 GM551338. Address correspondence to Deborah Leckband, Department of Chemical and Biomedical Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA. E-mail: leckband@uiuc.edu",

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doi = "10.1080/00218460490465713",

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Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

Abstract

Keywords

ASJC Scopus subject areas

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