Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

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This review highlights recent surface force measurements of the molecular interactions of protein adhesives. These studies identified novel molecular-binding mechanisms that are intimately linked to the protein structures. Central to these findings is the precise force and distance sensitivity achieved with the surface force apparatus. They illustrate that a mechanistic understanding of the nanomechanical properties of biomolecular adhesives requires measurements of both the strength of adhesion and the range of the protein interactions.

Original languageEnglish (US)
Pages (from-to)409-432
Number of pages24
JournalJournal of Adhesion
Issue number5
StatePublished - May 2004


  • Cadherin
  • CD2
  • Cell adhesion
  • NCAM
  • Polysialic acid
  • Surface force apparatus

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Computational Mechanics


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