Abstract

This review highlights recent surface force measurements of the molecular interactions of protein adhesives. These studies identified novel molecular-binding mechanisms that are intimately linked to the protein structures. Central to these findings is the precise force and distance sensitivity achieved with the surface force apparatus. They illustrate that a mechanistic understanding of the nanomechanical properties of biomolecular adhesives requires measurements of both the strength of adhesion and the range of the protein interactions.

Original languageEnglish (US)
Pages (from-to)409-432
Number of pages24
JournalJournal of Adhesion
Volume80
Issue number5
DOIs
StatePublished - May 1 2004

Fingerprint

Force measurement
Surface measurement
Cell adhesion
adhesion
proteins
Proteins
adhesives
Adhesives
cells
Molecular interactions
molecular interactions
Adhesion
sensitivity
interactions

Keywords

  • Cadherin
  • CD2
  • Cell adhesion
  • NCAM
  • Polysialic acid
  • Surface force apparatus

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Computational Mechanics

Cite this

Molecular mechanisms of cell adhesion : New perspectives from surface force measurements. / Leckband, Deborah.

In: Journal of Adhesion, Vol. 80, No. 5, 01.05.2004, p. 409-432.

Research output: Contribution to journalArticle

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