TY - JOUR
T1 - Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy
AU - Woźniak, Marcin
AU - Płoska, Agata
AU - Siekierzycka, Anna
AU - Dobrucki, Lawrence W.
AU - Kalinowski, Leszek
AU - Dobrucki, Iwona T.
N1 - This research was funded by the National Science Centre, grant no. 2019/33/B/NZ7/02699, and the Polish Ministry of Education and Science, grants no. DIR/WK/2017/01 and 10/E-389/SPUB/ SP/2020.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Personalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized medicine. Nanoparticles are widely used in MI techniques due to their size, high surface area to volume ratio, and multifunctional properties. After conjugation to specific ligands and drugs, nanoparticles can transport therapeutic compounds directly to their area of action and therefore may be used in theranostics—the simultaneous imple-mentation of treatment and diagnostics. This review summarizes different MI techniques, including optical imaging, ultrasound imaging, magnetic resonance imaging, nuclear imaging, and computed tomography imaging with theranostics nanoparticles. Furthermore, it explores the potential use of constructs that enables multimodal imaging and track diseases in real time.
AB - Personalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized medicine. Nanoparticles are widely used in MI techniques due to their size, high surface area to volume ratio, and multifunctional properties. After conjugation to specific ligands and drugs, nanoparticles can transport therapeutic compounds directly to their area of action and therefore may be used in theranostics—the simultaneous imple-mentation of treatment and diagnostics. This review summarizes different MI techniques, including optical imaging, ultrasound imaging, magnetic resonance imaging, nuclear imaging, and computed tomography imaging with theranostics nanoparticles. Furthermore, it explores the potential use of constructs that enables multimodal imaging and track diseases in real time.
KW - Imaging modalities
KW - Molecular imaging
KW - Nanoparticles
KW - Nanotechnology
KW - Personalized medicine
KW - Theranostics
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U2 - 10.3390/ijms23052658
DO - 10.3390/ijms23052658
M3 - Review article
C2 - 35269797
AN - SCOPUS:85125381856
SN - 1661-6596
VL - 23
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 5
M1 - 2658
ER -