Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

Jing Jing Zhang, Tian Lan, Yi Lu

Research output: Contribution to journalReview article

Abstract

Recent advances in nanotechnology and engineering have generated many nanomaterials with unique physical and chemical properties. Over the past decade, numerous nanomaterials are introduced into many research areas, such as sensors for environmental monitoring, food safety, point-of-care diagnostics, and as transducers for solar energy transfer. Meanwhile, functional nucleic acids (FNAs), including nucleic acid enzymes, aptamers, and aptazymes, have attracted major attention from the biomedical community due to their unique target recognition and catalytic properties. Benefiting from the recent progress of molecular engineering strategies, the physicochemical properties of nanomaterials are endowed by the target recognition and catalytic activity of FNAs in the presence of a target analyte, resulting in numerous smart nanoprobes for diverse applications including intracellular imaging, drug delivery, in vivo imaging, and tumor therapy. This progress report focuses on the recent advances in designing and engineering FNA-based nanomaterials, highlighting the functional outcomes toward in vivo applications. The challenges and opportunities for the future translation of FNA-based nanomaterials into clinical applications are also discussed.

Original languageEnglish (US)
Article number1801158
JournalAdvanced Healthcare Materials
Volume8
Issue number6
DOIs
StatePublished - Mar 21 2019

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Nanostructures
Nucleic acids
Nanostructured materials
Nucleic Acids
Point-of-Care Systems
Solar Energy
Nanoprobes
Imaging techniques
Food safety
Nanotechnology
Food Safety
Environmental Monitoring
Energy Transfer
Transducers
Drug delivery
Energy transfer
Solar energy
Chemical properties
Tumors
Catalyst activity

Keywords

  • DNAzyme
  • aptamers
  • functional nucleic acid
  • in vivo applications
  • nanomaterials

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications. / Zhang, Jing Jing; Lan, Tian; Lu, Yi.

In: Advanced Healthcare Materials, Vol. 8, No. 6, 1801158, 21.03.2019.

Research output: Contribution to journalReview article

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