Molecular dynamics simulations suggest that electrostatic funnel directs binding of Tamiflu to influenza N1 neuraminidases

Keyphrases

• Molecular Dynamics Simulation 100%
• Direct Binding 100%
• Electrostatic Funnel 100%
• Tamiflu 100%
• Influenza 100%
• Neuraminidase 100%
• Oseltamivir 75%
• Oseltamivir Resistance 50%
• Flu Virus 50%
• Steered Molecular Dynamics Simulation 25%
• Molecular Dynamics 25%
• Graphics Processing Unit 25%
• Binding Site 25%
• Point mutation 25%
• Dynamic Graphics 25%
• Antiviral Drugs 25%
• Virion 25%
• Drug Binding 25%
• Drug Resistance 25%
• Binding Pathway 25%
• A(H1N1)pdm09 25%
• New Drugs 25%
• Electrostatic Binding 25%
• Binding Funnel 25%
• Infected Individual 25%
• Swine Flu 25%
• H5N1 25%
• Resistance Mechanisms 25%
• Simulation Computation 25%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• Static Electricity 100%
• Oseltamivir 100%
• Sialidase 40%
• Neuraminidase 40%
• Binding Site 20%
• Pig 20%
• Point Mutation 20%
• Drug Resistance 20%
• Bird 20%
• Drug Binding 20%
• Influenza A Virus (H5N1) 20%
• Virion 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Oseltamivir 100%
• Influenza 42%
• Sialidase 28%
• Binding Site 14%
• Swine Influenza 14%
• Antivirus Agent 14%
• Ethinylestradiol Plus Norethisterone Acetate 14%
• Influenza A Virus (H5N1) 14%
• Bird 14%
• Drug Resistance 14%