@article{31091ec21e404cc6b9a038f4f02dcef6,
title = "Molecular dynamics simulation of an entire cell",
abstract = "The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell{\textquoteright}s components with atomic resolution. In contrast to their real-world counterparts, computational microscopes are currently on the brink of meeting this challenge. In this perspective, we show how an integrative approach can be employed to model an entire cell, the minimal cell, JCVI-syn3A, at full complexity. This step opens the way to interrogate the cell{\textquoteright}s spatio-temporal evolution with molecular dynamics simulations, an approach that can be extended to other cell types in the near future.",
keywords = "JCVI-syn3A, Martini force field, coarse grain, integrative modeling, minimal cell, polyply",
author = "Stevens, {Jan A.} and Fabian Gr{\"u}newald and {van Tilburg}, {P. A.Marco} and Melanie K{\"o}nig and Gilbert, {Benjamin R.} and Brier, {Troy A.} and Thornburg, {Zane R.} and Zaida Luthey-Schulten and Marrink, {Siewert J.}",
note = "Funding Information: SM acknowledges funding from the ERC with the Advanced grant 101053661 (“COMP-O-CELL”), and funding from NWO through the NWA grant “The limits to growth: The challenge to dissipate energy” and BaSyc (“Building a Synthetic Cell”) consortium. ZL-S acknowledges funding from NSF (MCB: 2221237 “Simulating a growing minimal cell: Integrating experiment and theory”; PHY: 1430124 “Center for the Physics of Living Cells”; PHY: 1505008 and 2014027 “Collaborative Research Network from Physics of Living Systems”). Publisher Copyright: Copyright {\textcopyright} 2023 Stevens, Gr{\"u}newald, van Tilburg, K{\"o}nig, Gilbert, Brier, Thornburg, Luthey-Schulten and Marrink.",
year = "2023",
month = jan,
day = "18",
doi = "10.3389/fchem.2023.1106495",
language = "English (US)",
volume = "11",
journal = "Frontiers in Chemistry",
issn = "2296-2646",
publisher = "Frontiers Media S. A.",
}