TY - JOUR
T1 - Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates
AU - Lee, Jung Heon
AU - Yigit, Mehmet V.
AU - Mazumdar, Debapriya
AU - Lu, Yi
N1 - Funding Information:
We thank the US National Institute of Health (ES016865) and the National Science Foundation (DMR-0117792, CTS-0120978 and DMI-0328162) for financial support.
PY - 2010/4
Y1 - 2010/4
N2 - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.
AB - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.
KW - Aptamer
KW - Biomedical
KW - Biosensor
KW - Diagnostics
KW - DNA
KW - Drug delivery
KW - Nanomaterials
KW - Targeted therapeutics
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U2 - 10.1016/j.addr.2010.03.003
DO - 10.1016/j.addr.2010.03.003
M3 - Review article
C2 - 20338204
AN - SCOPUS:77955667310
VL - 62
SP - 592
EP - 605
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 6
ER -