Abstract
Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 592-605 |
| Number of pages | 14 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 62 |
| Issue number | 6 |
| DOIs | |
| State | Published - Apr 1 2010 |
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Keywords
- Aptamer
- Biomedical
- Biosensor
- Diagnostics
- DNA
- Drug delivery
- Nanomaterials
- Targeted therapeutics
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates. / Lee, Jung Heon; Yigit, Mehmet V.; Mazumdar, Debapriya; Lu, Yi.
In: Advanced Drug Delivery Reviews, Vol. 62, No. 6, 01.04.2010, p. 592-605.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates
AU - Lee, Jung Heon
AU - Yigit, Mehmet V.
AU - Mazumdar, Debapriya
AU - Lu, Yi
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.
AB - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.
KW - Aptamer
KW - Biomedical
KW - Biosensor
KW - Diagnostics
KW - DNA
KW - Drug delivery
KW - Nanomaterials
KW - Targeted therapeutics
UR - http://www.scopus.com/inward/record.url?scp=77955667310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955667310&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2010.03.003
DO - 10.1016/j.addr.2010.03.003
M3 - Review article
C2 - 20338204
AN - SCOPUS:77955667310
VL - 62
SP - 592
EP - 605
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 6
ER -