Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Jung Heon Lee, Mehmet V. Yigit, Debapriya Mazumdar, Yi Lu

Research output: Contribution to journalReview article

Abstract

Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

Original languageEnglish (US)
Pages (from-to)592-605
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume62
Issue number6
DOIs
StatePublished - Apr 1 2010

Keywords

  • Aptamer
  • Biomedical
  • Biosensor
  • Diagnostics
  • DNA
  • Drug delivery
  • Nanomaterials
  • Targeted therapeutics

ASJC Scopus subject areas

  • Pharmaceutical Science

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