Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Jung Heon Lee; Mehmet V. Yigit; Debapriya Mazumdar; Yi Lu

doi:10.1016/j.addr.2010.03.003

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Jung Heon Lee, Mehmet V. Yigit, Debapriya Mazumdar, Yi Lu

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

Original language	English (US)
Pages (from-to)	592-605
Number of pages	14
Journal	Advanced Drug Delivery Reviews
Volume	62
Issue number	6
DOIs	https://doi.org/10.1016/j.addr.2010.03.003
State	Published - Apr 2010

Keywords

Aptamer
Biomedical
Biosensor
Diagnostics
DNA
Drug delivery
Nanomaterials
Targeted therapeutics

ASJC Scopus subject areas

Pharmaceutical Science

Online availability

10.1016/j.addr.2010.03.003

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title = "Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates",

abstract = "Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.",

keywords = "Aptamer, Biomedical, Biosensor, Diagnostics, DNA, Drug delivery, Nanomaterials, Targeted therapeutics",

author = "Lee, {Jung Heon} and Yigit, {Mehmet V.} and Debapriya Mazumdar and Yi Lu",

note = "Funding Information: We thank the US National Institute of Health (ES016865) and the National Science Foundation (DMR-0117792, CTS-0120978 and DMI-0328162) for financial support.",

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doi = "10.1016/j.addr.2010.03.003",

language = "English (US)",

volume = "62",

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AU - Lee, Jung Heon

AU - Yigit, Mehmet V.

AU - Mazumdar, Debapriya

AU - Lu, Yi

N1 - Funding Information: We thank the US National Institute of Health (ES016865) and the National Science Foundation (DMR-0117792, CTS-0120978 and DMI-0328162) for financial support.

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Y1 - 2010/4

N2 - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

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KW - Aptamer

KW - Biomedical

KW - Biosensor

KW - Diagnostics

KW - DNA

KW - Drug delivery

KW - Nanomaterials

KW - Targeted therapeutics

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Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Abstract

Keywords

ASJC Scopus subject areas

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