Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Jung Heon Lee, Mehmet V. Yigit, Debapriya Mazumdar, Yi Lu

Research output: Contribution to journalReview article

Abstract

Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

Original languageEnglish (US)
Pages (from-to)592-605
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume62
Issue number6
DOIs
StatePublished - Apr 1 2010

Fingerprint

Molecular Pathology
Nanostructures
Nanoparticles
Quantum Dots
Carbon Nanotubes
Gold
Pharmaceutical Preparations
Magnetic Resonance Imaging
Antibodies
ferric oxide

Keywords

  • Aptamer
  • Biomedical
  • Biosensor
  • Diagnostics
  • DNA
  • Drug delivery
  • Nanomaterials
  • Targeted therapeutics

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates. / Lee, Jung Heon; Yigit, Mehmet V.; Mazumdar, Debapriya; Lu, Yi.

In: Advanced Drug Delivery Reviews, Vol. 62, No. 6, 01.04.2010, p. 592-605.

Research output: Contribution to journalReview article

Lee, Jung Heon ; Yigit, Mehmet V. ; Mazumdar, Debapriya ; Lu, Yi. / Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates. In: Advanced Drug Delivery Reviews. 2010 ; Vol. 62, No. 6. pp. 592-605.
@article{2dec0e44844247a3abecaba6694d199d,
title = "Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates",
abstract = "Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.",
keywords = "Aptamer, Biomedical, Biosensor, Diagnostics, DNA, Drug delivery, Nanomaterials, Targeted therapeutics",
author = "Lee, {Jung Heon} and Yigit, {Mehmet V.} and Debapriya Mazumdar and Yi Lu",
year = "2010",
month = "4",
day = "1",
doi = "10.1016/j.addr.2010.03.003",
language = "English (US)",
volume = "62",
pages = "592--605",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

AU - Lee, Jung Heon

AU - Yigit, Mehmet V.

AU - Mazumdar, Debapriya

AU - Lu, Yi

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

AB - Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

KW - Aptamer

KW - Biomedical

KW - Biosensor

KW - Diagnostics

KW - DNA

KW - Drug delivery

KW - Nanomaterials

KW - Targeted therapeutics

UR - http://www.scopus.com/inward/record.url?scp=77955667310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955667310&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2010.03.003

DO - 10.1016/j.addr.2010.03.003

M3 - Review article

C2 - 20338204

AN - SCOPUS:77955667310

VL - 62

SP - 592

EP - 605

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 6

ER -