Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Jung Heon Lee; Mehmet V. Yigit; Debapriya Mazumdar; Yi Lu

doi:10.1016/j.addr.2010.03.003

Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates

Jung Heon Lee, Mehmet V. Yigit, Debapriya Mazumdar, Yi Lu

Research output: Contribution to journal › Review article

Abstract

Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold nanoparticles, quantum dots, carbon nanotubes, and superparamagnetic iron oxide nanoparticles, each with unique optical, magnetic, and electrochemical properties, are reviewed. Applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.

Original language	English (US)
Pages (from-to)	592-605
Number of pages	14
Journal	Advanced Drug Delivery Reviews
Volume	62
Issue number	6
DOIs	https://doi.org/10.1016/j.addr.2010.03.003
State	Published - Apr 1 2010

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Keywords

Aptamer
Biomedical
Biosensor
Diagnostics
DNA
Drug delivery
Nanomaterials
Targeted therapeutics

ASJC Scopus subject areas

Pharmaceutical Science

Cite this

Lee, J. H., Yigit, M. V., Mazumdar, D., & Lu, Y. (2010). Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates. Advanced Drug Delivery Reviews, 62(6), 592-605. https://doi.org/10.1016/j.addr.2010.03.003

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10.1016/j.addr.2010.03.003