Molecular diagnosis of cancer using multiplex photoacoustic imaging with targeted nanorods

Carolyn L. Bayer, Yun Sheng Chen, Seungsoo Kim, Srivalleesha Mallidi, Konstantin Sokolov, Stanislav Emelianov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The diagnosis and treatment of cancerous tumors remains a challenge due to the inherent heterogeneity of the tumors and variation in treatment response between patients. A molecular imaging technique which provides high resolution at a depth of several centimeters could provide important information about the composition of heterogeneous cancerous tissues to aid in the diagnosis and monitoring of the treatment of cancer. Photoacoustic imaging, which can achieve high resolution at a clinically relevant tissue depth, combined with targeted contrast agents whose properties can be tuned to achieve distinct photoacoustic signals, provides a molecular imaging technique which is non-invasive, non-ionizing, and cost-competitive in comparison to existing molecular imaging methods. The research presented here describes combined photoacoustic and ultrasound imaging using tunable gold nanorods which have been targeted to unique cell types or molecular processes, and then distinguished by acquiring photoacoustic images at laser wavelengths spanning the optical absorption spectra of the nanoparticles. The results obtained using tissue models consisting of various cancer cells, overexpressing different receptors, indicate that photoacoustic imaging is capable of identifying multiple molecular targets or cell types within a tissue.

Original languageEnglish (US)
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages503-506
Number of pages4
DOIs
StatePublished - Dec 1 2010
Externally publishedYes
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Other

Other2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

Keywords

  • gold nanoparticles
  • molecular imaging
  • photoacoustics
  • ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Fingerprint Dive into the research topics of 'Molecular diagnosis of cancer using multiplex photoacoustic imaging with targeted nanorods'. Together they form a unique fingerprint.

Cite this