Molecular determinants of bat wing development

K. E. Sears

Research output: Contribution to journalArticlepeer-review


The specialization of the forelimb into a wing allowed bats to become the only mammals to achieve powered flight. Recent studies in developmental biology have begun to elucidate the molecular mechanisms behind elements of this important morphological transformation. Specifically, researchers have identified molecular changes contributing to: the formation of the bat wing membrane, the elongation of skeletal elements of the bat wing and the reduction of the bat ulna. The general picture emerging from this research is that small changes in the expression of genes critical to many aspects of development have driven large changes in bat wing morphology. Thus, bats can be added to the growing list of groups in which expression changes in key developmental genes have been linked to the evolution of morphological innovations (e.g. early bilaterians, cetaceans, insects).

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalCells Tissues Organs
Issue number1
StatePublished - Dec 2007
Externally publishedYes


  • Chiroptera
  • Digit
  • Interdigital membrane
  • Ulna

ASJC Scopus subject areas

  • Anatomy
  • Histology


Dive into the research topics of 'Molecular determinants of bat wing development'. Together they form a unique fingerprint.

Cite this