Molecular Clock

Research output: Chapter in Book/Report/Conference proceedingChapter


The hypothesis of the molecular clock posits that the rate of evolution of a macromolecule is approximately constant over time and among different evolutionary lineages. Despite provoking many controversies since it was put forth in the early 1960s, the molecular clock has had remarkable influence on today's theories of molecular evolution and has inspired a number of tools for constructing evolutionary timescales.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013


  • Divergence
  • Evolutionary rate
  • Global clock
  • Local clock
  • Neutral theory
  • Phylogenetic tree
  • Relative-rate test
  • Species

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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