Molecular chaperone-mediated nuclear protein dynamics

Frank J. Echtenkamp, Brian C. Freeman

Research output: Contribution to journalArticle

Abstract

Homeostasis requires effective action of numerous biological pathways including those working along a genome. The variety of processes functioning in the nucleus is considerable, yet the number of employed factors eclipses this total. Ideally, individual components assemble into distinct complexes and serially operate along a pathway to perform work. Adding to the complexity is a multitude of fluctuating internal and external signals that must be monitored to initiate, continue or halt individual activities. While cooperative interactions between proteins of the same process provide a mechanism for rapid and precise assembly, the inherent stability of such organized structures interferes with the proper timing of biological events. Further prolonging the longevity of biological complexes are crowding effects resulting from the high concentration of intracellular macromolecules. Hence, accessory proteins are required to destabilize the various assemblies to efficiently transition between structures, avoid off-pathway competitive interactions, and to terminate pathway activity. We suggest that molecular chaperones have evolved, in part, to manage these challenges by fostering a general and continuous dynamic protein environment within the nucleus.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalCurrent Protein and Peptide Science
Volume15
Issue number3
StatePublished - Jan 1 2014

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Molecular Chaperones
Nuclear Proteins
Proteins
Foster Home Care
Accessories
Macromolecules
Homeostasis
Genes
Genome

Keywords

  • Molecular chaperone
  • Nucleus
  • Protein-DNA dynamics
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Molecular chaperone-mediated nuclear protein dynamics. / Echtenkamp, Frank J.; Freeman, Brian C.

In: Current Protein and Peptide Science, Vol. 15, No. 3, 01.01.2014, p. 216-224.

Research output: Contribution to journalArticle

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