Abstract
Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed bu using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 577-585 |
| Number of pages | 9 |
| Journal | Nature Materials |
| Volume | 2 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2003 |
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ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
Cite this
Molecular biomimetics : Nanotechnology through biology. / Sarikaya, Mehmet; Tamerler, Candan; Jen, Alex K.Y.; Schulten, Klaus; Baneyx, François.
In: Nature Materials, Vol. 2, No. 9, 09.2003, p. 577-585.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Molecular biomimetics
T2 - Nanotechnology through biology
AU - Sarikaya, Mehmet
AU - Tamerler, Candan
AU - Jen, Alex K.Y.
AU - Schulten, Klaus
AU - Baneyx, François
PY - 2003/9
Y1 - 2003/9
N2 - Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed bu using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.
AB - Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed bu using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.
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UR - http://www.scopus.com/inward/citedby.url?scp=0141780801&partnerID=8YFLogxK
U2 - 10.1038/nmat964
DO - 10.1038/nmat964
M3 - Review article
C2 - 12951599
AN - SCOPUS:0141780801
VL - 2
SP - 577
EP - 585
JO - Nature Materials
JF - Nature Materials
SN - 1476-1122
IS - 9
ER -