Molecular biomimetics: Nanotechnology through biology

Mehmet Sarikaya; Candan Tamerler; Alex K.Y. Jen; Klaus Schulten; François Baneyx

doi:10.1038/nmat964

Molecular biomimetics: Nanotechnology through biology

Mehmet Sarikaya, Candan Tamerler, Alex K.Y. Jen, Klaus Schulten, François Baneyx

Physics

Research output: Contribution to journal › Review article › peer-review

Abstract

Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed bu using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.

Original language	English (US)
Pages (from-to)	577-585
Number of pages	9
Journal	Nature Materials
Volume	2
Issue number	9
DOIs	https://doi.org/10.1038/nmat964
State	Published - Sep 2003

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Molecular biomimetics: Nanotechnology through biology",

abstract = "Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed bu using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.",

author = "Mehmet Sarikaya and Candan Tamerler and Jen, {Alex K.Y.} and Klaus Schulten and Fran{\c c}ois Baneyx",

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AU - Baneyx, François

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