Molecular basis for resistance against phosphonate antibiotics and herbicides

Jonathan R. Chekan, Dillon P. Cogan, Satish K. Nair

Research output: Contribution to journalReview article

Abstract

Research studies in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review the current state of knowledge of the structural and biochemical characterization of resistance mechanisms against these bioactive natural products. Advances in the understanding of these resistance determinants have spurred knowledge-based campaigns aimed at the design of derivatives that retain biological activity but are less prone to tolerance.

Original languageEnglish (US)
Pages (from-to)28-36
Number of pages9
JournalMedChemComm
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2016

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glyphosate
Fosfomycin
Organophosphonates
Herbicides
Bioactivity
Biological Products
Anti-Bacterial Agents
Derivatives
Research
fosmidomycin
phosphonic acid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this

Molecular basis for resistance against phosphonate antibiotics and herbicides. / Chekan, Jonathan R.; Cogan, Dillon P.; Nair, Satish K.

In: MedChemComm, Vol. 7, No. 1, 01.01.2016, p. 28-36.

Research output: Contribution to journalReview article

Chekan, Jonathan R. ; Cogan, Dillon P. ; Nair, Satish K. / Molecular basis for resistance against phosphonate antibiotics and herbicides. In: MedChemComm. 2016 ; Vol. 7, No. 1. pp. 28-36.
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