Molecular basis for resistance against phosphonate antibiotics and herbicides

Jonathan R. Chekan, Dillon P. Cogan, Satish K. Nair

Research output: Contribution to journalReview articlepeer-review


Research studies in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review the current state of knowledge of the structural and biochemical characterization of resistance mechanisms against these bioactive natural products. Advances in the understanding of these resistance determinants have spurred knowledge-based campaigns aimed at the design of derivatives that retain biological activity but are less prone to tolerance.

Original languageEnglish (US)
Pages (from-to)28-36
Number of pages9
Issue number1
StatePublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


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