TY - JOUR
T1 - Molecular and neuronal substrates for general anaesthetics
AU - Rudolph, Uwe
AU - Antkowiak, Bernd
N1 - Funding Information:
The authors would like to acknowledge the dedicated work of R. Jurd, M. Arras, S. Lambert and others on the β3(N265M) mouse model discussed in this review. The work was supported by the Swiss National Science Foundation (U.R.), the Deutsche Forschungsgemeinschaft (B.A.) and the Interdisciplinary Center for Clinical Research (IZKF) Tübingen (B.A.).
PY - 2004/9
Y1 - 2004/9
N2 - Although general anaesthesia has been of tremendous importance for the development of surgery, the underlying mechanisms by which this state is achieved are only just beginning to be understood in detail. In this review, we describe the neuronal systems that are thought to be involved in mediating clinically relevant actions of general anaesthetics, and we go on to discuss how the function of individual drug targets, in particular GABAA- receptor subtypes, can be revealed by genetic studies in vivo.
AB - Although general anaesthesia has been of tremendous importance for the development of surgery, the underlying mechanisms by which this state is achieved are only just beginning to be understood in detail. In this review, we describe the neuronal systems that are thought to be involved in mediating clinically relevant actions of general anaesthetics, and we go on to discuss how the function of individual drug targets, in particular GABAA- receptor subtypes, can be revealed by genetic studies in vivo.
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U2 - 10.1038/nrn1496
DO - 10.1038/nrn1496
M3 - Review article
C2 - 15322529
AN - SCOPUS:4344574333
SN - 1471-003X
VL - 5
SP - 709
EP - 720
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 9
ER -