Molecular and neuronal substrates for general anaesthetics

Uwe Rudolph, Bernd Antkowiak

Research output: Contribution to journalReview articlepeer-review


Although general anaesthesia has been of tremendous importance for the development of surgery, the underlying mechanisms by which this state is achieved are only just beginning to be understood in detail. In this review, we describe the neuronal systems that are thought to be involved in mediating clinically relevant actions of general anaesthetics, and we go on to discuss how the function of individual drug targets, in particular GABAA- receptor subtypes, can be revealed by genetic studies in vivo.

Original languageEnglish (US)
Pages (from-to)709-720
Number of pages12
JournalNature Reviews Neuroscience
Issue number9
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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