Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Tong Qing An; Jiang Nan Li; Chia Ming Su; Dongwan Yoo

doi:10.1016/j.virusres.2020.197980

Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Tong Qing An, Jiang Nan Li, Chia Ming Su, Dongwan Yoo

Research output: Contribution to journal › Review article

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.

Original language	English (US)
Article number	197980
Journal	Virus Research
Volume	286
DOIs	https://doi.org/10.1016/j.virusres.2020.197980
State	Published - Sep 2020

ASJC Scopus subject areas

Cancer Research
Virology
Infectious Diseases

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10.1016/j.virusres.2020.197980

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An, T. Q., Li, J. N., Su, C. M., & Yoo, D. (2020). Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection. Virus Research, 286, [197980]. https://doi.org/10.1016/j.virusres.2020.197980

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abstract = "Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.",

author = "An, {Tong Qing} and Li, {Jiang Nan} and Su, {Chia Ming} and Dongwan Yoo",

year = "2020",

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language = "English (US)",

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AU - Li, Jiang Nan

AU - Su, Chia Ming

AU - Yoo, Dongwan

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N2 - Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.

AB - Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.

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