Molecular analysis of mouse rab11b: A new type of mammalian ypt/rab protein

Fang Lai, Lisa Stubbs, Karen Artzt

Research output: Contribution to journalArticle

Abstract

Since the realization that the vesicular transport machinery is conserved from yeast to vertebrate neurons, much interest in the proteins involved has been generated. Here we describe a new type of mammalian YPT/Rab protein, named Rab11b, that is most abundantly expressed in brain, heart, and testis. It has all the hallmarks of a YPT3/Rab11 protein, but is more closely related to a ypt3 -related gene isolated from fish (97% homology) than to the previously described four mammalian Rab11 genes (89% homology). The mammalian Rab11 genes discovered previously are, by contrast, 100% identical to each other. The genomic structure of a mammalian Rab11 protein is described for the first time. It is surprisingly asymmetrical, with 96% of the coding sequence contained in one-third of the transcription unit. Two copies of this gene are mapped to mouse chromosomes 1 and 17, The fine structural analysis of Rab11b and the protein sequence comparison provides a close look at all YPT3/Rab11 -related genes cloned so far and clues to their possible relationship.

Original languageEnglish (US)
Pages (from-to)610-616
Number of pages7
JournalGenomics
Volume22
Issue number3
DOIs
StatePublished - Aug 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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