Modulation of RNA tertiary folding by incorporation of caged nucleotides

Claudia Höbartner; Scott K. Silverman

doi:10.1002/anie.200502928

Modulation of RNA tertiary folding by incorporation of caged nucleotides

Claudia Höbartner, Scott K. Silverman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Knock it off: Individual RNA nucleotides with a caged nucleobase were incorporated, through their phosphoramidites, into a 160-mer RNA molecule that adopts a specific tertiary structure (see picture). Position-dependent local and global effects on RNA structure were observed, and photocleavage of the caging group was seen to restore the native folding.

Original language	English (US)
Pages (from-to)	7305-7309
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	44
DOIs	https://doi.org/10.1002/anie.200502928
State	Published - Nov 11 2005

Keywords

Caging
Nucleobases
Oligonucleotides
Photolysis
RNA structures

ASJC Scopus subject areas

Catalysis
General Chemistry

Online availability

10.1002/anie.200502928

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KW - Oligonucleotides

KW - Photolysis

KW - RNA structures

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Modulation of RNA tertiary folding by incorporation of caged nucleotides

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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