Modulation of RNA tertiary folding by incorporation of caged nucleotides

Claudia Höbartner, Scott K. Silverman

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Knock it off: Individual RNA nucleotides with a caged nucleobase were incorporated, through their phosphoramidites, into a 160-mer RNA molecule that adopts a specific tertiary structure (see picture). Position-dependent local and global effects on RNA structure were observed, and photocleavage of the caging group was seen to restore the native folding.

Original languageEnglish (US)
Pages (from-to)7305-7309
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number44
DOIs
StatePublished - Nov 11 2005

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Keywords

  • Caging
  • Nucleobases
  • Oligonucleotides
  • Photolysis
  • RNA structures

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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