Modulation of RNA tertiary folding by incorporation of caged nucleotides

Claudia Höbartner, Scott K Silverman

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Knock it off: Individual RNA nucleotides with a caged nucleobase were incorporated, through their phosphoramidites, into a 160-mer RNA molecule that adopts a specific tertiary structure (see picture). Position-dependent local and global effects on RNA structure were observed, and photocleavage of the caging group was seen to restore the native folding.

Original languageEnglish (US)
Pages (from-to)7305-7309
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number44
DOIs
StatePublished - Nov 11 2005

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Nucleotides
RNA
Modulation
Molecules

Keywords

  • Caging
  • Nucleobases
  • Oligonucleotides
  • Photolysis
  • RNA structures

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Modulation of RNA tertiary folding by incorporation of caged nucleotides. / Höbartner, Claudia; Silverman, Scott K.

In: Angewandte Chemie - International Edition, Vol. 44, No. 44, 11.11.2005, p. 7305-7309.

Research output: Contribution to journalArticle

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