@article{9b0abbb34f41431d82a90ed602c0e003,
title = "Modulation of immune response in Ebola virus disease",
abstract = "Ebola virus disease targets and destroys immune cells, including macrophages and dendritic cells, leading to impairment of host response. After infection, a combination of strategies including alteration and evasion of immune response culminating in a strong inflammatory response can lead to multi-organ failure and death in most infected patients. This review discusses immune response dynamics, mainly focusing on how Ebola manipulates innate and adaptive immune responses and strategizes to thwart host immune responses. We also discuss the challenges and prospects of developing therapeutics and vaccines against Ebola.",
keywords = "Ebola, Filoviruses, Immune evasion, Interferons, Pathogenicity",
author = "Goutam Banerjee and Kamal Shokeen and Nilanjan Chakraborty and Saumya Agarwal and Arindam Mitra and Sachin Kumar and Pratik Banerjee",
note = "Funding Information: The work in the University of Illinois is partially supported by a USDA-NIFA project (project # ILLU-698-981). The virus research work in the laboratory at IIT Guwahati is supported by grants from the Department of Biotechnology, Government of India (BT/PR24308/NER/95/644/2017 and BT/562/NE/U-Excel/2016). Funding Information: The work in the University of Illinois is partially supported by a USDA- NIFA project (project # ILLU-698-981 ). The virus research work in the laboratory at IIT Guwahati is supported by grants from the Department of Biotechnology , Government of India ( BT/PR24308/NER/95/644/2017 and BT/562/NE/U-Excel/2016 ). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = oct,
doi = "10.1016/j.coph.2021.07.004",
language = "English (US)",
volume = "60",
pages = "158--167",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",
}