Modulation of immune response in Ebola virus disease

Goutam Banerjee, Kamal Shokeen, Nilanjan Chakraborty, Saumya Agarwal, Arindam Mitra, Sachin Kumar, Pratik Banerjee

Research output: Contribution to journalReview articlepeer-review


Ebola virus disease targets and destroys immune cells, including macrophages and dendritic cells, leading to impairment of host response. After infection, a combination of strategies including alteration and evasion of immune response culminating in a strong inflammatory response can lead to multi-organ failure and death in most infected patients. This review discusses immune response dynamics, mainly focusing on how Ebola manipulates innate and adaptive immune responses and strategizes to thwart host immune responses. We also discuss the challenges and prospects of developing therapeutics and vaccines against Ebola.

Original languageEnglish (US)
Pages (from-to)158-167
Number of pages10
JournalCurrent Opinion in Pharmacology
StatePublished - Oct 2021


  • Ebola
  • Filoviruses
  • Immune evasion
  • Interferons
  • Pathogenicity

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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