Modulating synaptic plasticity with metal−organic framework for information-filterable artificial retina

Seongchan Kim, Ohchan Kwon, Seonkwon Kim, Seonmin Jang, Seungho Yu, Choong Hoo Lee, Yoon Young Choi, Soo Young Cho, Ki Chul Kim, Cunjiang Yu, Dae Woo Kim, Jeong Ho Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroprosthetics equipped with artificial synapses hold promise to address some most intricate medical problems, such as human sensory disorders. Yet, it is necessitated and of paramount importance for neuroprosthetics to be able to differentiate significant and insignificant signals. Here, we present an information-filterable artificial retina system that integrates artificial synapses with a signal-integration device for signal perception and processing with attention. The synaptic weight modulation is rendered through metal–organic framework (MOF) layers, where distinct short-term and long-term properties are predominantly determined by MOF’s pore diameter and functionality. Specifically, four types of isoreticular Zr-based MOFs that share Zr6O4(OH)4 secondary building units have been systematically examined. It is demonstrated that small pore diameters enhance short-term properties, while large pores, which are characterized by increased ion affinity, sustain long-term properties. Moreover, we demonstrated a 6 × 6 pixel artificial retina by incorporating both short-term and long-term artificial synapses with a signal-integration device. Signal summation by the signal-integration device enables attention-based information processing. The information-filterable artificial retina system developed here emulates human perception processes and holds promise in the fields of neuroprosthetics and advanced artificial intelligence.

Original languageEnglish (US)
Article number162
JournalNature communications
Volume16
Issue number1
DOIs
StatePublished - Dec 2025

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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