Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Daniel J. Blair; Martin D. Burke

doi:10.1038/d41586-020-02565-1

Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Daniel J. Blair
, Martin D. Burke

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.

Original language	English (US)
Pages (from-to)	32-33
Number of pages	2
Journal	Nature
Volume	586
Issue number	7827
Early online date	Sep 23 2020
DOIs	https://doi.org/10.1038/d41586-020-02565-1
State	Published - Oct 1 2020

Keywords

Drug discovery
Organic chemistry
Structural biology
Synthesis

ASJC Scopus subject areas

General

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10.1038/d41586-020-02565-1

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title = "Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance",

abstract = "An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.",

keywords = "Drug discovery, Organic chemistry, Structural biology, Synthesis",

author = "Blair, \{Daniel J.\} and Burke, \{Martin D.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2020.",

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doi = "10.1038/d41586-020-02565-1",

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AU - Blair, Daniel J.

AU - Burke, Martin D.

N1 - Publisher Copyright: © Springer Nature Limited 2020.

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Y1 - 2020/10/1

N2 - An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.

AB - An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.

KW - Drug discovery

KW - Organic chemistry

KW - Structural biology

KW - Synthesis

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U2 - 10.1038/d41586-020-02565-1

DO - 10.1038/d41586-020-02565-1

M3 - Comment/debate

C2 - 32968245

AN - SCOPUS:85092119468

SN - 0028-0836

VL - 586

SP - 32

EP - 33

JO - Nature

JF - Nature

IS - 7827

ER -

Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Abstract

Keywords

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