Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Daniel J. Blair, Martin D. Burke

Research output: Contribution to journalComment/debatepeer-review

Abstract

An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.

Original languageEnglish (US)
Pages (from-to)32-33
Number of pages2
JournalNature
Volume586
Issue number7827
Early online dateSep 23 2020
DOIs
StatePublished - Oct 1 2020

Keywords

  • Drug discovery
  • Organic chemistry
  • Structural biology
  • Synthesis

ASJC Scopus subject areas

  • General

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