Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Daniel J. Blair; Martin D. Burke

doi:10.1038/d41586-020-02565-1

Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.

Original language	English (US)
Pages (from-to)	32-33
Number of pages	2
Journal	Nature
Volume	586
Issue number	7827
Early online date	Sep 23 2020
DOIs	https://doi.org/10.1038/d41586-020-02565-1
State	Published - Oct 1 2020

Keywords

Drug discovery
Organic chemistry
Structural biology
Synthesis

ASJC Scopus subject areas

General

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10.1038/d41586-020-02565-1

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title = "Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance",

abstract = "An ancient resistance mechanism poses a problem when using streptogramin antibiotics. A modular approach to drug synthesis exploits this same mechanism to generate an antibiotic that avoids the emergence of resistance.",

keywords = "Drug discovery, Organic chemistry, Structural biology, Synthesis",

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KW - Structural biology

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Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance

Abstract

Keywords

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