Modular peptide growth factors for substrate-mediated stem cell differentiation

Jae Sam Lee, Jae Sung Lee, Amy Wagoner-Johnson, William L. Murphy

Research output: Contribution to journalArticlepeer-review


The sequence specificity of the binding of a modular peptide growth factor (eBGa3) that contains a BMP2-derived sequence and a mineral-binding sequence inspired by osteocalcin to calcium ions of hydroxyapatite (HA) may be attributed in part to evolution of an α-helical structure in the presence of HA, which allows for registration of γ-carboxylated glutamic acid residues in the peptide (cyan) with calcium atoms (orange) in the HA crystal lattice.

Original languageEnglish (US)
Pages (from-to)6266-6269
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number34
StatePublished - Aug 10 2009


  • Biomineralization
  • Hydroxyapatite
  • Osteocalcin
  • Osteogenesis
  • Protein modifications

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis
  • General Medicine


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