Abstract
The sequence specificity of the binding of a modular peptide growth factor (eBGa3) that contains a BMP2-derived sequence and a mineral-binding sequence inspired by osteocalcin to calcium ions of hydroxyapatite (HA) may be attributed in part to evolution of an α-helical structure in the presence of HA, which allows for registration of γ-carboxylated glutamic acid residues in the peptide (cyan) with calcium atoms (orange) in the HA crystal lattice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6266-6269 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 34 |
| DOIs | |
| State | Published - Aug 10 2009 |
Keywords
- Biomineralization
- Hydroxyapatite
- Osteocalcin
- Osteogenesis
- Protein modifications
ASJC Scopus subject areas
- General Chemistry
- Catalysis
- General Medicine