Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA.

Y. Ike, R. A. Craig, B. A. White, Y. Yagi, D. B. Clewell

Research output: Contribution to journalArticlepeer-review

Abstract

Recipient strains of Streptococcus faecalis excrete multiple, peptide sex pheromones that induce mating responses in donors harboring certain conjugative plasmids. Acquisition of plasmid DNA leads to a "shutting off" of pheromone excretion, and such cells become responsive to exogenous pheromone. Data are presented showing that donors excrete low levels of a modified, inactive form of the pheromone. This substance, when mixed in excess with active pheromone, inhibits pheromone activity (probably by competition for a receptor site on the donor). Modified forms of both cPD1 and cAD1 were revealed, and each appeared to have a mass about 350-400 daltons larger than the active pheromone. In both cases, pheromone activity could be regenerated by treatment with phosphodiesterase II.

Original languageEnglish (US)
Pages (from-to)5369-5373
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number17
DOIs
StatePublished - Sep 1983

ASJC Scopus subject areas

  • General

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