TY - JOUR
T1 - Moderate-to-Vigorous Physical Activity is Related With Retinal Neuronal and Axonal Integrity in Persons With Multiple Sclerosis
AU - Kim, Jeongwoon
AU - Bollaert, Rachel E.
AU - Cerna, Jonathan
AU - Adamson, Brynn C.
AU - Robbs, Connor M.
AU - Khan, Naiman A.
AU - Motl, Robert W.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the University of Illinois Paul D. Doolen Graduate Scholarship for the Study of Aging and the National Multiple Sclerosis Society.
Publisher Copyright:
© The Author(s) 2022.
PY - 2022/12
Y1 - 2022/12
N2 - Background: Moderate-to-vigorous physical activity (MVPA) may confer benefits for axonal and/or neuronal integrity in adults with multiple sclerosis (MS). Purpose: Examine the association between device-measured MVPA with optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with and without MS. Methods: Adults with MS (N = 41), along with sex-matched healthy control (HC) participants (N = 79), underwent measurements of retinal morphology via OCT and wore an accelerometer for a period of 7 days as a measure of MVPA. Results: Persons with MS had significantly lower MVPA, RNFL thickness, and TMV compared with HCs. MVPA was correlated with RNFL (r =.38, P <.01) thickness and TMV (r =.49, P <.01). Hierarchical linear regression analyses indicated that addition of MVPA attenuated the Group effect on RNFL and TMV. MVPA accounted for 8% and 3% of the variance in TMV (β =.343, P <.01) and RNFL thickness (β =.217, P =.03), respectively. Conclusion: MVPA was positively associated with axonal and neuronal integrity assessed by OCT and partially explained group differences in those metrics. These results present possible future targets for MS management by increasing MVPA.
AB - Background: Moderate-to-vigorous physical activity (MVPA) may confer benefits for axonal and/or neuronal integrity in adults with multiple sclerosis (MS). Purpose: Examine the association between device-measured MVPA with optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with and without MS. Methods: Adults with MS (N = 41), along with sex-matched healthy control (HC) participants (N = 79), underwent measurements of retinal morphology via OCT and wore an accelerometer for a period of 7 days as a measure of MVPA. Results: Persons with MS had significantly lower MVPA, RNFL thickness, and TMV compared with HCs. MVPA was correlated with RNFL (r =.38, P <.01) thickness and TMV (r =.49, P <.01). Hierarchical linear regression analyses indicated that addition of MVPA attenuated the Group effect on RNFL and TMV. MVPA accounted for 8% and 3% of the variance in TMV (β =.343, P <.01) and RNFL thickness (β =.217, P =.03), respectively. Conclusion: MVPA was positively associated with axonal and neuronal integrity assessed by OCT and partially explained group differences in those metrics. These results present possible future targets for MS management by increasing MVPA.
KW - moderate-to-vigorous physical activity
KW - multiple sclerosis
KW - optical coherence tomography
KW - retinal nerve fiber layer
KW - total macular volume
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U2 - 10.1177/15459683221131787
DO - 10.1177/15459683221131787
M3 - Article
C2 - 36317869
AN - SCOPUS:85141425085
SN - 1545-9683
VL - 36
SP - 810
EP - 815
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
IS - 12
ER -