Moderate physical activity mediates the association between white matter lesion volume and memory recall in breast cancer survivors

Gillian E. Cooke, Nathan C. Wetter, Sarah E. Banducci, Michael J. Mackenzie, Krystle E. Zuniga, Elizabeth A. Awick, Sarah A. Roberts, Brad P. Sutton, Edward McAuley, Arthur F. Kramer

Research output: Contribution to journalArticle

Abstract

Increased survival rates among breast cancer patients have drawn significant attention to consequences of both the presence of cancer, and the subsequent treatment-related impact on the brain. The incidence of breast cancer and the effects of treatment often result in alterations in the microstructure of white matter and impaired cognitive functioning. However, physical activity is proving to be a successful modifiable lifestyle factor in many studies that could prove beneficial to breast cancer survivors. This study investigates the link between white matter lesion volume, moderate physical activity, and cognition in breast cancer survivors following treatment compared to non-cancer age-matched controls. Results revealed that brain structure significantly predicted cognitive function via mediation of physical activity in breast cancer survivors. Overall, the study provided preliminary evidence suggesting moderate physical activity may help reduce the treatment related risks associated with breast cancer, including changes to WM integrity and cognitive impairment.

Original languageEnglish (US)
Article numbere0149552
JournalPloS one
Volume11
Issue number2
DOIs
StatePublished - Feb 2016

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lesions (animal)
physical activity
breast neoplasms
Survivors
Brain
Exercise
Breast Neoplasms
Data storage equipment
cognition
Cognition
Microstructure
brain
Second Primary Neoplasms
microstructure
lifestyle
White Matter
Life Style
Therapeutics
Survival Rate
survival rate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Cooke, G. E., Wetter, N. C., Banducci, S. E., Mackenzie, M. J., Zuniga, K. E., Awick, E. A., ... Kramer, A. F. (2016). Moderate physical activity mediates the association between white matter lesion volume and memory recall in breast cancer survivors. PloS one, 11(2), [e0149552]. https://doi.org/10.1371/journal.pone.0149552

Moderate physical activity mediates the association between white matter lesion volume and memory recall in breast cancer survivors. / Cooke, Gillian E.; Wetter, Nathan C.; Banducci, Sarah E.; Mackenzie, Michael J.; Zuniga, Krystle E.; Awick, Elizabeth A.; Roberts, Sarah A.; Sutton, Brad P.; McAuley, Edward; Kramer, Arthur F.

In: PloS one, Vol. 11, No. 2, e0149552, 02.2016.

Research output: Contribution to journalArticle

Cooke, GE, Wetter, NC, Banducci, SE, Mackenzie, MJ, Zuniga, KE, Awick, EA, Roberts, SA, Sutton, BP, McAuley, E & Kramer, AF 2016, 'Moderate physical activity mediates the association between white matter lesion volume and memory recall in breast cancer survivors', PloS one, vol. 11, no. 2, e0149552. https://doi.org/10.1371/journal.pone.0149552
Cooke, Gillian E. ; Wetter, Nathan C. ; Banducci, Sarah E. ; Mackenzie, Michael J. ; Zuniga, Krystle E. ; Awick, Elizabeth A. ; Roberts, Sarah A. ; Sutton, Brad P. ; McAuley, Edward ; Kramer, Arthur F. / Moderate physical activity mediates the association between white matter lesion volume and memory recall in breast cancer survivors. In: PloS one. 2016 ; Vol. 11, No. 2.
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