Modelling of bone fracture and strength at different length scales: A review

Fereshteh A. Sabet, Ahmad Raeisi Najafi, Elham Hamed, Iwona Jasiuk

Research output: Contribution to journalReview article

Abstract

In this paper, we review analytical and computational models of bone fracture and strength. Bone fracture is a complex phenomenon due to the composite, inhomogeneous and hierarchical structure of bone. First, we briefly summarize the hierarchical structure of bone, spanning from the nanoscale, sub-microscale, microscale,mesoscale to the macroscale, and discuss experimental observations on failure mechanisms in bone at these scales. Then,we highlight representative analytical and computational models of bone fracture and strength at different length scales and discuss the main findings in the context of experiments. We conclude by summarizing the challenges in modelling of bone fracture and strength and list open topics for scientific exploration. Modelling of bone, accounting for different scales, provides new and needed insights into the fracture and strength of bone, which, in turn, can lead to improved diagnostic tools and treatments of bone diseases such as osteoporosis.

Original languageEnglish (US)
Article number20150055
JournalInterface Focus
Volume6
Issue number1
DOIs
StatePublished - Feb 6 2016

Keywords

  • Bone fracture
  • Bone strength
  • Computational modeling
  • Hierarchical structure
  • Multiscale modelling

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

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