Modeling Parasite Infection Dynamics when there Is Heterogeneity and Imperfect Detectability

Na Cui, Yuguo Chen, Dylan S. Small

Research output: Contribution to journalArticle

Abstract

Understanding the infection and recovery rate from parasitic infections is valuable for public health planning. Two challenges in modeling these rates are (1) infection status is only observed at discrete times even though infection and recovery take place in continuous time and (2) detectability of infection is imperfect. We address these issues through a Bayesian hierarchical model based on a random effects Weibull distribution. The model incorporates heterogeneity of the infection and recovery rate among individuals and allows for imperfect detectability. We estimate the model by a Markov chain Monte Carlo algorithm with data augmentation. We present simulation studies and an application to an infection study about the parasite Giardia lamblia among children in Kenya.

Original languageEnglish (US)
Pages (from-to)683-692
Number of pages10
JournalBiometrics
Volume69
Issue number3
DOIs
StatePublished - Sep 2013

Keywords

  • Bayesian Hierarchical Model
  • Infection Rate
  • Markov Chain Monte Carlo
  • Panel Data
  • Recovery Rate
  • Two-state Process

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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