Modeling of cortical bone adaptation in a rat ulna: Effect of frequency

N. Chennimalai Kumar, J. A. Dantzig, I. M. Jasiuk

Research output: Contribution to journalArticlepeer-review

Abstract

We employ a recently developed model for the adaptation of cortical bone in response to mechanical loading to study the effect of loading frequency on the computed response, and we compare our results to previous experimental measurements on rat ulnae. We represent the cortical bone as a poroelastic material with orthotropic permeability. Bone adaptation in the model is related to a mechanical stimulus derived from the dissipation energy of the poroelastic flow induced by deformation. We account for a non-locality in the mechanotransduction of osteocytes present in the lacunae by using a "zone of influence". Calculations are done using the finite element method applied to a rat ulna whose geometry is obtained from micro-computed tomography images. We show that the change in the second moment of inertia of the cross-section increases non-linearly and saturates at higher frequency range. The numerical results are then compared quantitatively to experimental data from the literature. Finally, we examine the role of local narrowing of intramedullary canal in our specific ulna in the development of local irregularities in growth.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalBone
Volume50
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • Cortical bone adaptation
  • Dissipation energy
  • Evolution law
  • Finite element modeling
  • Interstitial fluid flow
  • Poroelasticity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Fingerprint Dive into the research topics of 'Modeling of cortical bone adaptation in a rat ulna: Effect of frequency'. Together they form a unique fingerprint.

Cite this