Modeling fourier transform infrared spectroscopic imaging of Prostate and Breast Cancer tissue specimens

Rohith Reddy, Brynmor Davis, Paul Scott Carney, Rohit Bhargava

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Fourier transform infrared (FT-IR) spectroscopic imaging is an emerging technique that provides both spatially and chemically resolved information. The rich chemical content of data may be utilized for computer-aided determinations of structure and pathologic state (cancer diagnosis) in histological tissue sections for Prostate and Breast Cancer. Recent results show that tissue type (histological) classification can be performed to an accuracy [1] of 94% to 99% and cancer diagnosis can be performed with an accuracy of about [2] 80% on a microscopic ( 6m) length scale. One of the primary causes of reduction in classification accuracy is the systematic errors caused by distortions in the infrared spectra of tissues resulting from the nature of data acquisition. Here, we present a rigorous model for the interaction of infrared light with the tissue sample using coupled wave analysis and characterize the nature of these distortions. In particular, we demonstrate the spectral effects of changing the thickness of homogeneous samples and scattering from boundaries of two regions in spatially heterogeneous samples. Modeling these optical distortions provides a fundamental understanding of systematic errors in FT-IR measurements and is important to improving accuracy of automated cancer tissue histopathology.

Original languageEnglish (US)
Title of host publication2011 8th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI'11
Pages738-741
Number of pages4
DOIs
StatePublished - Nov 2 2011
Event2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 - Chicago, IL, United States
Duration: Mar 30 2011Apr 2 2011

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
CountryUnited States
CityChicago, IL
Period3/30/114/2/11

Keywords

  • Cancer
  • FT-IR
  • Infrared
  • Spectroscopic Imaging
  • Tissue classification

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Reddy, R., Davis, B., Carney, P. S., & Bhargava, R. (2011). Modeling fourier transform infrared spectroscopic imaging of Prostate and Breast Cancer tissue specimens. In 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 (pp. 738-741). [5872511] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2011.5872511