Modeling and measurement of tissue elastic moduli using optical coherence elastography

Xing Liang, Amy L. Oldenburg, Vasilica Crecea, Sureshkumar Kalyanam, Michael F. Insana, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mechanical forces play crucial roles in tissue growth, patterning and development. To understand the role of mechanical stimuli, biomechanical properties are of great importance, as well as our ability to measure biomechanical properties of developing and engineered tissues. To enable these measurements, a novel non-invasive, micron-scale and high-speed Optical Coherence Elastography (OCE) system has been developed utilizing a titanium: sapphire based spectral-domain Optical Coherence Tomography (OCT) system and a mechanical wave driver. This system provides axial resolution of 3 microns, transverse resolution of 13 microns, and an acquisition rate as high as 25,000 lines per second. External low-frequency vibrations are applied to the samples in the system. Step and sinusoidal steady-state responses are obtained to first characterize the OCE system and then characterize samples. Experimental results of M-mode OCE on silicone phantoms and human breast tissues are obtained, which correspond to biomechanical models developed for this analysis. Quantified results from the OCE system correspond directly with results from an indentation method from a commercial. With micron-scale resolution and a high-speed acquisition rate, our OCE system also has the potential to rapidly measure dynamic 3-D tissue biomechanical properties.

Original languageEnglish (US)
Title of host publicationOptics in Tissue Engineering and Regenerative Medicine II
DOIs
StatePublished - Jun 26 2008
EventOptics in Tissue Engineering and Regenerative Medicine II - San Jose, CA, United States
Duration: Jan 20 2008Jan 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6858
ISSN (Print)1605-7422

Other

OtherOptics in Tissue Engineering and Regenerative Medicine II
CountryUnited States
CitySan Jose, CA
Period1/20/081/21/08

Keywords

  • Optical coherence elastography
  • Silicone
  • Tissue phantom
  • Young's modulus

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Liang, X., Oldenburg, A. L., Crecea, V., Kalyanam, S., Insana, M. F., & Boppart, S. A. (2008). Modeling and measurement of tissue elastic moduli using optical coherence elastography. In Optics in Tissue Engineering and Regenerative Medicine II [685803] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6858). https://doi.org/10.1117/12.760779