@article{c65353989c484a5c943939f6e8461730,
title = "Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions",
abstract = "A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 351 investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.",
keywords = "Airway, Chronic infection, Cystic fibrosis, Models, Polymicrobial",
author = "O{\textquoteright}Toole, {George A.} and Aur{\'e}lie Crabb{\'e} and Rolf K{\"u}mmerli and LiPuma, {John J.} and Bomberger, {Jennifer M.} and Davies, {Jane C.} and Dominique Limoli and Phelan, {Vanessa V.} and Bliska, {James B.} and DePas, {William H.} and Dietrich, {Lars E.} and Hampton, {Thomas H.} and Ryan Hunter and Khursigara, {Cezar M.} and Alexa Price-Whelan and Alix Ashare and Cramer, {Robert A.} and Goldberg, {Joanna B.} and Freya Harrison and Hogan, {Deborah A.} and Henson, {Michael A.} and Madden, {Dean R.} and Mayers, {Jared R.} and Carey Nadell and Dianne Newman and Alice Prince and Rivett, {Damian W.} and Schwartzman, {Joseph D.} and Daniel Schultz and Sheppard, {Donald C.} and Smyth, {Alan R.} and Spero, {Melanie A.} and Stanton, {Bruce A.} and Turner, {Paul E.} and {van der Gast}, Chris and Whelan, {Fiona J.} and Rachel Whitaker and Katrine Whiteson",
note = "Publisher Copyright: Copyright {\textcopyright} 2021 O{\textquoteright}Toole et al.",
year = "2021",
month = oct,
day = "1",
doi = "10.1128/mBio.01763-21",
language = "English (US)",
volume = "12",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "5",
}