Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance

David K. Karig, Piro Siuti, Roy David Dar, Scott T. Retterer, Mitchel J. Doktycz, Michael L. Simpson

Research output: Contribution to journalArticle

Abstract

Cells offer natural examples of highly efficient networks of nanomachines. Accordingly, both intracellular and intercellular communication mechanisms in nature are looked to as a source of inspiration and instruction for engineered nanocommunication. Harnessing biological functionality in this manner requires an interdisciplinary approach that integrates systems biology, synthetic biology, and nanofabrication. Here, we present a model system that exemplifies the synergism between these realms of research. We propose a synthetic gene network for operation in a nanofabricated cell mimic array that propagates a biomolecular signal over long distances using the phenomenon of stochastic resonance. Our system consists of a bacterial quorum sensing signal molecule, a bistable genetic switch triggered by this signal, and an array of nanofabricated cell mimic wells that contain the genetic system. An optimal level of noise in the system helps to propagate a time-varying AHL signal over long distances through the array of mimics. This noise level is determined both by the system volume and by the parameters of the genetic network. Our proposed genetically driven stochastic resonance system serves as a testbed for exploring the potential harnessing of gene expression noise to aid in the transmission of a time-varying molecular signal.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalNano Communication Networks
Volume2
Issue number1
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Fingerprint

Stochastic Resonance
Communication
Cell
Testbeds
Nanotechnology
Gene expression
Genes
Switches
Molecules
Time-varying
Model
Quorum Sensing
Nanofabrication
Synergism
Synthetic Biology
Genetic Network
Gene Networks
Systems Biology
Testbed
Gene Expression

Keywords

  • Cell mimic
  • Noise
  • Quorum sensing
  • Stochastic resonance
  • Synthetic biology

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance. / Karig, David K.; Siuti, Piro; Dar, Roy David; Retterer, Scott T.; Doktycz, Mitchel J.; Simpson, Michael L.

In: Nano Communication Networks, Vol. 2, No. 1, 01.03.2011, p. 39-49.

Research output: Contribution to journalArticle

Karig, David K. ; Siuti, Piro ; Dar, Roy David ; Retterer, Scott T. ; Doktycz, Mitchel J. ; Simpson, Michael L. / Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance. In: Nano Communication Networks. 2011 ; Vol. 2, No. 1. pp. 39-49.
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