Model-based analysis of two-color arrays (MA2C)

Jun S. Song, W. Evan Johnson, Xiaopeng Zhu, Xinmin Zhang, Wei Li, Arjun K. Manrai, Jun S. Liu, Runsheng Chen, X. Shirley Shirley

Research output: Contribution to journalArticlepeer-review


A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control.

Original languageEnglish (US)
Article numberR178
JournalGenome biology
Issue number8
StatePublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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