Mixed quantum/classical dynamics of hydrogen transfer reactions

Sharon Hammes-Schiffer

Research output: Contribution to journalReview articlepeer-review


This article presents the methodology we have developed for the simulation of hydrogen transfer reactions, including multiple proton transfer and proton-coupled electron transfer reactions. The central method discussed is molecular dynamics with quantum transitions (MDQT), which is a mixed quantum/classical surface hopping method that incorporates nonadiabatic transitions between the proton vibrational and/or electronic states. The advantages of MDQT are that it accurately describes branching processes (i.e., processes involving multiple pathways), is valid in the adiabatic and nonadiabatic limits and the intermediate regime, and provides realtime dynamical information. The multiconfigurational MDQT (MC-MDQT) method combines MDQT with an MC-SCF formulation of the vibrational modes for the simulation of processes involving multiple quantum modes (e.g., for multiple proton transfer reactions). MC-MDQT incorporates the significant correlation between the quantum modes in a computationally practical way and has been applied to proton transport along water chains. The EV-MDQT method incorporates transitions between mixed electronic/proton vibrational adiabatic states, which are calculated in a way that removes the standard double adiabatic aproximation. EV-MDQT has been applied to model proton-coupled electron transfer reactions. These new developments allow the simulation of a wide range of biologically and chemically important hydrogen transfer processes.

Original languageEnglish (US)
Pages (from-to)X-10454
JournalJournal of Physical Chemistry A
Issue number51
StatePublished - Dec 17 1998

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry


Dive into the research topics of 'Mixed quantum/classical dynamics of hydrogen transfer reactions'. Together they form a unique fingerprint.

Cite this