Mitotic chromosome structure and condensation

Andrew S. Belmont

doi:10.1016/j.ceb.2006.09.007

Mitotic chromosome structure and condensation

Research output: Contribution to journal › Review article › peer-review

Abstract

Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.

Original language	English (US)
Pages (from-to)	632-638
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.ceb.2006.09.007
State	Published - Dec 2006

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2006.09.007

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title = "Mitotic chromosome structure and condensation",

abstract = "Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.",

author = "Belmont, {Andrew S.}",

note = "Funding Information: This work was supported by NIH grant GM42516.",

year = "2006",

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AB - Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.

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Mitotic chromosome structure and condensation

Abstract

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