Mitigating the risk of African swine fever virus in feed with anti-viral chemical additives

Megan C. Niederwerder, Scott Dee, Diego G. Diel, Ana M.M. Stoian, Laura A. Constance, Matthew Olcha, Vlad Petrovan, Gilbert Patterson, Ada G. Cino-Ozuna, Raymond R.R. Rowland

Research output: Contribution to journalArticlepeer-review


African swine fever (ASF) is currently considered the most significant global threat to pork production worldwide. Disease caused by the ASF virus (ASFV) results in high case fatality of pigs. Importantly, ASF is a trade-limiting disease with substantial implications on both global pork and agricultural feed commodities. ASFV is transmissible through natural consumption of contaminated swine feed and is broadly stable across a wide range of commonly imported feed ingredients and conditions. The objective of the current study was to investigate the efficacy of medium-chain fatty acid and formaldehyde-based feed additives in inactivating ASFV. Feed additives were tested in cell culture and in feed ingredients under a transoceanic shipment model. Both chemical additives reduced ASFV infectivity in a dose-dependent manner. This study provides evidence that chemical feed additives may potentially serve as mitigants for reducing the risk of ASFV introduction and transmission through feed.

Original languageEnglish (US)
Pages (from-to)477-486
Number of pages10
JournalTransboundary and Emerging Diseases
Issue number2
StatePublished - Mar 2021
Externally publishedYes


  • ASFV
  • African swine fever virus
  • animal feed
  • anti-infective agents
  • domestic pig
  • food additives
  • ships
  • swine diseases
  • virus inactivation

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Veterinary


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