Siltation inside a harbor built on the Mississippi River downstream of St. Louis, MO has been a problem since the harbor started operating. This study presents an assessment of the causes of siltation and recommendations for sediment management strategies. A comparison between the characteristics of the sediment found in the harbor and the suspended and bed material in the river showed that the wash load of the Mississippi River enters the harbor and deposits due to the lack of flow-through velocities. Characteristic discharges in the river and associated suspended sediment concentrations were computed to determine the thresholds above which significant siltation can be expected. The times of the year in which siltation is more prominent were also determined, and potential sediment management strategies were proposed as part of this study.