TY - JOUR
T1 - Mismatch between self-reported quality of life and functional assessment in acute mania
T2 - A matter of unawareness of illness?
AU - Gazalle, Fernando Kratz
AU - Frey, Benício Noronha
AU - Hallal, Pedro Curi
AU - Andreazza, Ana Cristina
AU - Cunha, Ângelo Batista M.
AU - Santin, Aida
AU - Kapczinski, Flávio
N1 - Funding Information:
This study was supported in part by CNPq, CAPES and FIPE-HCPA (Brazil).
PY - 2007/11
Y1 - 2007/11
N2 - Background: Studies addressing self-reported quality of life (QoL) in acute mania are scarce and inconsistent. While it has been suggested that there is some disagreement between objective measures and subjective QoL as reported by acutely manic patients, this issue has not been systematically studied. This study aims to investigate the self-reported QoL in manic, depressed, and euthymic BD subjects, as compared to matched healthy controls. Methods: One-hundred and twenty type-I bipolar patients (40 manic, 40 depressed, and 40 euthymic) and 40 matched controls were studied. Self-reported QoL was assessed using the World Health Organization's Quality of Life Instrument-Short Version (WHOQOL-BREF). Objective functioning was assessed using the Global Assessment of Functioning (GAF), and depressive and manic symptoms were assessed using the Hamilton Depression Rating Scale-17 items (HDRS) and the Young Mania Rating Scale (YMRS), respectively. Results: Manic patients presented the lowest GAF measures but reported same overall QoL as euthymic patients and controls, and better QoL than depressed patients. Within the manic subgroup, there was a significant inverse correlation between psychological QoL and GAF scores (r = - 0.54; p = 0.001). Limitations: The cross-sectional design and the lack of control for potential comorbid conditions are the major limitations of the present study. Conclusions: Our findings suggest that this mismatch between objective and subjective measures during acute mania may be associated with a lack of insight or awareness of their own illness.
AB - Background: Studies addressing self-reported quality of life (QoL) in acute mania are scarce and inconsistent. While it has been suggested that there is some disagreement between objective measures and subjective QoL as reported by acutely manic patients, this issue has not been systematically studied. This study aims to investigate the self-reported QoL in manic, depressed, and euthymic BD subjects, as compared to matched healthy controls. Methods: One-hundred and twenty type-I bipolar patients (40 manic, 40 depressed, and 40 euthymic) and 40 matched controls were studied. Self-reported QoL was assessed using the World Health Organization's Quality of Life Instrument-Short Version (WHOQOL-BREF). Objective functioning was assessed using the Global Assessment of Functioning (GAF), and depressive and manic symptoms were assessed using the Hamilton Depression Rating Scale-17 items (HDRS) and the Young Mania Rating Scale (YMRS), respectively. Results: Manic patients presented the lowest GAF measures but reported same overall QoL as euthymic patients and controls, and better QoL than depressed patients. Within the manic subgroup, there was a significant inverse correlation between psychological QoL and GAF scores (r = - 0.54; p = 0.001). Limitations: The cross-sectional design and the lack of control for potential comorbid conditions are the major limitations of the present study. Conclusions: Our findings suggest that this mismatch between objective and subjective measures during acute mania may be associated with a lack of insight or awareness of their own illness.
KW - Anosognosia
KW - Bipolar disorder
KW - Insight
KW - Mania
KW - Psychosis
KW - Quality of life
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U2 - 10.1016/j.jad.2007.01.013
DO - 10.1016/j.jad.2007.01.013
M3 - Article
C2 - 17289153
AN - SCOPUS:34548825397
SN - 0165-0327
VL - 103
SP - 247
EP - 252
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-3
ER -