Miniaturized platforms for the detection of single-nucleotide polymorphisms

Johnson Kian Kok Ng, Wen Tso Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Conventional methods for detecting single-nucleotide polymorphisms (SNPs), the most common form of genetic variation in human beings, are mostly limited by their analysis time and throughputs. In contrast, advances in microfabrication technology have led to the development of miniaturized platforms that can potentially provide rapid high-throughput analysis at small sample volumes. This review highlights some of the recent developments in the miniaturization of SNP detection platforms, including microarray-based, bead-based microfluidic and microelectrophoresis-based platforms. Particular attention is paid to their ease of fabrication, analysis time, and level of throughput.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalAnalytical and bioanalytical chemistry
Volume386
Issue number3
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Hybridization
  • Microarrays
  • Microfluidics
  • Miniaturization
  • Single-nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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