TY - JOUR
T1 - Mineralized collagen scaffolds for regenerative engineering applications
AU - Kolliopoulos, Vasiliki
AU - Harley, Brendan AC
N1 - The authors would like to acknowledge financial support from the National Institute of Dental and Craniofacial Research of the National Institutes of Health (USA) under Award number R01 DE030491 (BACH) as well as National Institute of Arthritis and Musculoskeletal and Skin Diseases (USA) under Award number R01 AR077858 (BACH). We are also grateful for funds provided by the National Science Foundation (USA) Graduate Research Fellowship DGE-1746047 (VK) and the Chemistry-Biology Interface Research Training Program at the University of Illinois (USA) from of the National Institutes of Health (USA) under Award number T32 GM070421 , VK. The interpretations and conclusions presented are those of the authors and are not necessarily endorsed by the National Institutes of Health or the National Science Foundation.
PY - 2024/4
Y1 - 2024/4
N2 - Collagen is a primary constituent of the tissue extracellular matrix. As a result, collagen has been a common component of tissue engineering biomaterials, including those to promote bone regeneration or to investigate cell-material interactions in the context of bone homeostasis or disease. This review summarizes key considerations regarding current state-of-the-art design and use of collagen biomaterials for these applications. We also describe strategic opportunities for collagen biomaterials to address a new era of challenges, including immunomodulation and appropriate consideration of sex and other patient characteristics in biomaterial design.
AB - Collagen is a primary constituent of the tissue extracellular matrix. As a result, collagen has been a common component of tissue engineering biomaterials, including those to promote bone regeneration or to investigate cell-material interactions in the context of bone homeostasis or disease. This review summarizes key considerations regarding current state-of-the-art design and use of collagen biomaterials for these applications. We also describe strategic opportunities for collagen biomaterials to address a new era of challenges, including immunomodulation and appropriate consideration of sex and other patient characteristics in biomaterial design.
UR - https://www.scopus.com/pages/publications/85185831965
UR - https://www.scopus.com/pages/publications/85185831965#tab=citedBy
U2 - 10.1016/j.copbio.2024.103080
DO - 10.1016/j.copbio.2024.103080
M3 - Review article
C2 - 38402689
AN - SCOPUS:85185831965
SN - 0958-1669
VL - 86
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
M1 - 103080
ER -