Mindfulness training induces structural connectome changes in insula networks

Paul B. Sharp, Brad Sutton, Erick J. Paul, Nikolai Sherepa, Charles H. Hillman, Neal J Cohen, Arthur F. Kramer, Ruchika Shaurya Prakash, Wendy Heller, Eva H. Telzer, Aron Keith Barbey

Research output: Contribution to journalArticle

Abstract

Although mindfulness meditation is known to provide a wealth of psychological benefits, the neural mechanisms involved in these effects remain to be well characterized. A central question is whether the observed benefits of mindfulness training derive from specific changes in the structural brain connectome that do not result from alternative forms of experimental intervention. Measures of whole-brain and node-level structural connectome changes induced by mindfulness training were compared with those induced by cognitive and physical fitness training within a large, multi-group intervention protocol (n = 86). Whole-brain analyses examined global graph-theoretical changes in structural network topology. A hypothesis-driven approach was taken to investigate connectivity changes within the insula, which was predicted here to mediate interoceptive awareness skills that have been shown to improve through mindfulness training. No global changes were observed in whole-brain network topology. However, node-level results confirmed a priori hypotheses, demonstrating significant increases in mean connection strength in right insula across all of its connections. Present findings suggest that mindfulness strengthens interoception, operationalized here as the mean insula connection strength within the overall connectome. This finding further elucidates the neural mechanisms of mindfulness meditation and motivates new perspectives about the unique benefits of mindfulness training compared to contemporary cognitive and physical fitness interventions.

Original languageEnglish (US)
Article number7929
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - May 21 2018

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Connectome
Mindfulness
Meditation
Physical Fitness
Brain
Psychology

ASJC Scopus subject areas

  • General

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Mindfulness training induces structural connectome changes in insula networks. / Sharp, Paul B.; Sutton, Brad; Paul, Erick J.; Sherepa, Nikolai; Hillman, Charles H.; Cohen, Neal J; Kramer, Arthur F.; Prakash, Ruchika Shaurya; Heller, Wendy; Telzer, Eva H.; Barbey, Aron Keith.

In: Scientific Reports, Vol. 8, No. 1, 7929, 21.05.2018.

Research output: Contribution to journalArticle

Sharp, Paul B. ; Sutton, Brad ; Paul, Erick J. ; Sherepa, Nikolai ; Hillman, Charles H. ; Cohen, Neal J ; Kramer, Arthur F. ; Prakash, Ruchika Shaurya ; Heller, Wendy ; Telzer, Eva H. ; Barbey, Aron Keith. / Mindfulness training induces structural connectome changes in insula networks. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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