Microscopic detection analysis of single molecules in MoS2membrane nanopores

Mingye Xiong, Michael Graf, Nagendra Athreya, Aleksandra Radenovic, Jean Pierre Leburton

Research output: Contribution to journalArticlepeer-review

Abstract

A systematic microscopic analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS2 nanoribbon is presented. The variations of the transverse electronic current along the two-dimensional (2D) membrane due to the translocation of DNA and protein molecules through the pore are obtained by model calculations based on molecular dynamics (MD) and Boltzmann transport formalism, which achieved good agreement with the experimental data. Our analysis points to a selfconsistent interaction among ions, charge carriers around the pore rim, and biomolecules. It provides a comprehensive understanding of the effects of the electrolyte concentration, pore size, nanoribbon geometry, and also the doping polarity of the nanoribbon on the electrical sensitivity of the nanopore in detecting biomolecules. These results can be utilized for finetuning the design parameters in the fabrication of highly sensitive 2D nanopore biosensors.

Original languageEnglish (US)
Pages (from-to)16131-16139
Number of pages9
JournalACS Nano
Volume14
Issue number11
DOIs
StatePublished - Nov 24 2020

Keywords

  • 2D materials
  • Biosensing
  • Electron transport
  • Molecular dynamics
  • Nanopores

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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